Background: A phytochemical 5-demethylnobiletin from Citrus reticulata Blanco has a broad spectrum of pharmacological effects on anti-inflammatory, cardiovascular and neuroprotective effects, however, its in vivo effect on depigmentation remains unknown.Objective: To investigate how 5-demethylnobiletin regulates melanogenesis, both in vitro and in
Abstract Background Serological testing based on different antibody types are an alternative method being used to diagnose SARS-CoV-2 and has the potential of having higher diagnostic accuracy compared to the current gold standard Milk Powder rRT-PCR.Therefore, the objective of this review was to evaluate the diagnostic accuracy of IgG and IgM base
The notion that mitochondria cannot be lost was shattered with the report of an oxymonad Monocercomonoides exilis, the NAILCARE first eukaryote arguably without any mitochondrion.Yet, questions remain about whether this extends beyond the single species and how this transition took place.The Oxymonadida is a group of gut endobionts taxonomically ho
Unusual nucleic acid structures are salient triggers of endogenous repair and can occur in sequence-specific contexts.Peptide nucleic acids (PNAs) rely on these principles to achieve non-enzymatic gene editing.By forming high-affinity heterotriplex structures within the genome, PNAs have been used to correct multiple human chair disease-relevant mu